This episode is a conversation with Drs. Clifford Jack and Kevin Duff about recent updates to the diagnosis and staging of Alzheimer’s disease (AD). We discuss biological versus clinical/pathological approaches to diagnosing AD, analogies between AD and other medical conditions, the predictive validity of amyloid PET in asymptomatic older adults, the specific purpose of the recent Alzheimer's Association diagnosis and staging paper, the utility of currently available AD biomarkers, the status of blood-based biomarkers for AD, the amyloid hypothesis, concerns from neuropsychologists about the recent Alzheimer's Association biological definition of AD, and current state of the science for antiamyloid treatments in AD, among other topics.

Show notes are available at www.NavNeuro.com/156

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