Navigating Mast Cell Activation Syndrome (MCAS) with Jess Lewis (Episode 122)

An episode that explores the intricate connections between MCAS, autism, and POTS through a neurodivergent lens and the principles of functional medicine. Jess Lewis joins Matt and Angela to share her personal journey, the impact of medical gaslighting, and practical strategies for mast cell stabilization.

Here’s what’s in store for today’s episode:

* In today’s episode, we explore the link between MCAS and autism with special guest Jess Lewis — a functional medicine and trauma-informed neurodiversity advocate who supports individuals living with MCAS.

* Jess talks about how getting COVID and being around mold kicked her mast cells into overdrive.

* When our bodies are under too much stress, a dysregulated nervous system can send our mast cells into overdrive. Since autistic people are being forced to navigate a neurotypical world, we are more prone to this.

* We delve into the experience of medical gaslighting and the struggle to access supportive care while living with MCAS.

* Additionally, we discuss the importance of a low-histamine diet when managing MCAS and how it can play a key role in reducing symptoms.

* Our hosts and Jess explore the connection between POTS and autism, and share strategies for calming and stabilizing overactive mast cells.

* We then dive into the topic of anaphylaxis and how it can occur when mast cells become severely dysregulated. Jess breaks down what happens in the body during an anaphylactic response — and how, in those with MCAS, even seemingly minor triggers can lead to a cascade of symptoms when the immune system is already in a heightened state of alert.

* Finally, we explore the intersection of practical and functional medicine, and how blending both approaches can offer more comprehensive support for those with complex conditions like MCAS.

“When you go to the doctor, think about it like a work meeting. Have a plan, have an agenda, have the questions laid out. Use your superpowers of deep research. Bring studies - not to be combative, but just to say, ‘I wanna colaborate on this. Here’s what I’m seeing, here’s what I’m thinking. And if your doctor doesn’t wanna listen to you, go find another doctor. Feel good about the boundaries you put in front of yourself, because you gotta advocate.” - Jess Lewis

“If I can change one mind, I can change several minds… If I could change things for just a few people to have the lightbulb go off, to say, ‘I’ve got your back. I want to be the advocate for you. I want you to be the advocate for yourself.” - Jess Lewis

Did you enjoy this episode? We took a deep dive into the intersection of MCAS, autism, and neurodivergent health experiences. From medical gaslighting to the overlap with POTS and nervous system dysregulation, we unpack what it means to live in a body that's constantly on high alert. We also explore the importance of functional medicine, low-histamine diets, and practical strategies for mast cell stabilization. Join the convo with #AutisticCultureCatch!

Jess Lewis (she/they) is a Chief Technology Officer, turned MCAS researcher, and founder of the Mast Cell Support community. After reversing her own severe case of MCAS triggered by COVID and mold exposure, Jess now helps others heal using an evidence-based, neurodivergent-friendly approach rooted in functional medicine and trauma-informed care. She’s currently pursuing a PhD in Functional Medicine with a specialty in Mast Cell health and comorbidities, and brings a deep, systems-thinking lens to both her health advocacy and her continued leadership in tech.

Show Notes

Threads, Instagram, Substack: @jesslewisAdditional info and links: https://subscribepage.io/jesslewis

jesslewis.comCommunity - https://community.mastcellsupport.com/invitation

Food Guide Pharmacy

https://en.wikipedia.org/wiki/Quercetin

Related Episodes:

Autistic Medical Needs (Episode 14)Meat Body Maintenance (Episode 53)Autistic Medical Needs, Part 2 (Episode 108)

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