Identifying abnormal protein aggregates in early onset dementia

Scientists have discovered abnormal aggregates of a protein called TAF-15 in the brains of individuals with early onset dementia, known as Fronto-Temporal Dementia. This finding could potentially serve as a target for future diagnostic tests and treatments. The researchers used cryo-electron microscopy to study protein aggregates in the brains and identified TAF-15 as the key protein responsible. This discovery transforms our understanding of the molecular basis of Fronto-Temporal Dementia.