Better Brain Fitness (a Brainjo Production) 18: Does Cannabis Damage The Brain?
May 26, 2023
Dive into the long-term effects of cannabis on brain health, exploring its intriguing relationship with endocannabinoid receptors. Discover how cannabis affects adolescent brain development and learning pathways, and the potential for reversing damage. The discussion highlights cognitive declines linked to chronic use and emphasizes the structural changes in the brain. Learn about the differences between THC and CBD, their respective benefits, and the lifestyle factors that influence cognitive health.
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THC's Brain Impact Mechanism
- THC binds to CB1 and CB2 receptors, mainly disrupting brain function via CB1 receptors in critical areas like hippocampus and prefrontal cortex.
- This causes acute cognitive effects such as memory impairment, reduced attention, and coordination issues.
Adolescence Critical for THC Effects
- Animal studies show adolescent exposure to THC disrupts synaptic plasticity, impairing learning and memory.
- These brain changes can persist into adulthood without intervention, highlighting vulnerability during adolescence.
Long-Term Use Affects Cognition and Structure
- Long-term heavy cannabis use (4+ times weekly) links to mild neurocognitive decline, especially in verbal memory and executive function.
- MRI studies indicate dose-dependent prefrontal cortex thinning associated with cannabis use.