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Multiple Myeloma Hub

How to select maintenance therapies post-ASCT for patients with high-risk MM?

Sep 18, 2023
Experts Shaji Kumar and Naresh Bumma discuss selecting maintenance therapies post-ASCT for high-risk MM. They debate lenalidomide monotherapy vs. combination therapy with a proteosome inhibitor, the challenges of defining high-risk populations, and the need for prospective trials. Kumar and Bumma share their management strategies and highlight the future of managing high-risk MM post-ASCT.
20:31

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Quick takeaways

  • Defining high-risk MM challenges include varied cytogenetic definitions, like 17p deletions and translocations, prompting a need for consensus statements.
  • The benefits of combination maintenance therapies, including bortezomib and lenalidomide, are crucial for achieving deeper responses in high-risk MM patients post-ASCT.

Deep dives

Challenges in Defining High-Risk Patients

Defining high-risk multiple myeloma patients presents challenges due to varying definitions of high-risk cytogenetics, including factors like 17p deletions, translocation 4;14, translocation 14;16, and gain 1q. Ambiguities exist in classifying 1q gain and amplification. Discussions are ongoing to establish consensus statements to bring clarity and consistency to clinical trials.

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