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VJHemOnc Podcast
Addressing the importance of lymphodepletion, factors contributing to ICAHT & the cost effectiveness of CAR-T therapy
Feb 29, 2024
Exploring the importance of lymphodepletion in CAR-T therapy, addressing factors contributing to ICAHT, and discussing the cost effectiveness of CAR-T treatment. Insights from experts on personalized dosing, toxicity reduction, and financial implications of these agents.
13:02
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Quick takeaways
- Lymphodepletion is vital for preparing the body and tumor for CAR-T infusion.
- ICAHT pathogenesis involves patient factors and personalized treatment strategies.
Deep dives
Importance of Lympho Depletion in CAR-T Cell Cycle
Lympho depletion is a crucial component of the CAR-T cell cycle, preparing the body, immune system, microenvironment, and tumor for the infusion of CAR-T cells. Research highlighted the lack of scientific basis for different regimens used, leading to an emphasis on personalizing doses to balance efficacy and toxicity. Contributions from colleagues like Sloan Kettering in devising pharmacokinetic indexes aim to improve dose accuracy, though challenges persist in predicting actual thresholds for individual patients.
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