Selma Blair on Acting Through Adversity and the Power of Positivity

Selma Blair is an actress, author, and advocate whose career has spanned film, television and stage, with standout performances in Legally Blonde, Cruel Intentions, and Hellboy. After publicly revealing her diagnosis with multiple sclerosis (MS), she has become a powerful voice for chronic illness awareness, inspiring others through her honesty, resilience, and vulnerability. Selma sits down with Hoda to discuss her lifelong health struggles, her relationship with her late mother and the strength that carried her through acting, motherhood and moments of uncertainty. She reflects on her friendships with fellow stars navigating MS, including Christina Applegate and Jamie-Lynn Sigler, and why she refuses to let anything stand in the way of the life she’s determined to live.

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