This conversation with Yuri Deigin was recorded on June 25th, 2021. In this interview, Daniel Belkin and Mitch Belkin speak with Yuri about aging, which he argues is fundamentally an epigenetic phenomenon. We discuss partial reprogramming using Yamanaka factors, evolutionary explanations of aging, and recent in vivo experiments which suggest that aging is partially reversible. We also touch on mRNA vaccines, specifically to address allegations about the cytotoxicity of the spike protein and concerns about infertility discussed on Bret Weinstein’s Dark Horse Podcast with Steve Kirsch and Robert Malone, MD, recorded on June 11th 2021.

Who is Yuri Deigin?

Yuri Deigin is a biotech entrepreneur with a background in pharmaceutical development. He received degrees in computer science and mathematics from the University of Toronto and an MBA from Columbia University. He is the CEO of Youthereum Genetics, a company which aims to translate epigenetic rejuvenation therapies to humans. 

Yuri was an early proponent of the SARS-CoV-2 lab leak hypothesis, the idea that the virus may have inadvertently escaped from a lab. In April 2020, he published a detailed genomic analysis of SARS-CoV-2. In that article, Yuri discusses the virus’s furin cleavage site, genetic similarities and differences with its closest relative (RaTG13), and the similarities between the virus’s receptor binding motif and that of a pangolin respiratory virus. He also explores the gain-of-function research program at the Wuhan Institute of Virology. Unfortunately, we did not have time in this conversation to delve into this hotly debated topic.

References:

Universal methylation age across mammalian species

Partial reprogramming of Progeria mice

David Sinclair paper on restoring vision in mice

Uri Manor Lab spike protein paper 

Large doses of Spike Protein Induce Acute Lung Injury in Mice

Pfizer ADME study (translated from Japanese) 

Vaccine Adverse Event Reporting System (VAERS) FAQ re: requirement to report deaths, other serious adverse events

How frequently are side effects reported to VAERS?

More on Yuri:

Medium article on SARS-CoV-2 Origins

Yuri’s twitter: @ydeigin

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What is the External Medicine Podcast?

The External Medicine Podcast explores some of the most exciting ideas in medicine. Co-hosted by Daniel Belkin, MD, and Mitch Belkin, MD.

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