OncoPharm Trastuzumab
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Dec 31, 2020 Delve into the remarkable journey of trastuzumab, a game-changing cancer therapy stemming from the HER2 gene discovery. Discover how groundbreaking clinical trials and collaborations have paved the way for its use in breast cancer treatment, showcasing inspiring patient success stories. The discussion also highlights the drug's efficacy and safety, including potential risks like cardiomyopathy, ongoing monitoring strategies, and evolving treatment advancements for HER2-positive cases.
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Trastuzumab Development Anecdote
- Trastuzumab's development story includes a serendipitous meeting between researchers Ulrich and Sleiman at an airport.
- A patient named Barbara participated in early trials and became a 28-year disease-free survivor, showcasing the drug's impact.
Trastuzumab's Impact in Metastatic Cancer
- Trastuzumab improves survival significantly in metastatic breast cancer with notable response rates.
- The number needed to treat to save one life at one year is nine, indicating strong efficacy.
Adjuvant Trastuzumab's Cure Rate
- In the adjuvant breast cancer setting, trastuzumab reduces death risk with a number needed to treat between 12 and 20.
- This demonstrates a substantial effect size for a cancer drug in curing patients.