Metagenics Institute Podcast Resolving Inflammation using SPMs with Prof Charles Serhan
Aug 5, 2019
52:08
Professor Serhan expands on the application of SPMs inside the inflammation-resolution cycle and outside this cycle, highlighting alternative mechanisms, the wide scope of SPM therapy and exciting new treatment considerations currently within the field of lipid research.
- Prof Serhan background on moving into studying lipid mediators. (1:30)
- Aspirin triggers biosynthesis of lipid mediators. (4:57)
- Old to new: Review of inflammation and stimulating resolution processes. (6:55)
- Resolvins reduce neutrophilic infiltration and inducing “self-limitation”. (11:14)
- Plasticity of macrophage poles – key function of SPMs. (13:48)
- Healthy human breast milk contains SPMs. (19:45)
- Structures, receptors and functional location of Resolvins. (20:44)
- Downregulation of biosynthetic enzymes and using SPMs. (25:00)
- Aged mice with enhanced inflammatory response and diminished resolution response. (29:00)
- SPMs in obesity models. (31:00)
- Role of SPMs in additional chronic inflammatory conditions. (40:05)
- SPM killing and clearance of infections without immune suppression. (44:34)
- SPMs, macrophage types and tumor reduction. (46:45)
- Topical SPM application in animal models. (49:51)
- Future publication on periodontal disease. (52:53)