TWiV 1212: Clinical update with Dr. Daniel Griffin

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Apr 26, 2025

Joining the discussion is Dr. Daniel Griffin, an infectious disease physician and clinical expert. He talks about the troubling US withdrawal from global health initiatives and the importance of vaccination against diseases like avian flu and measles. Dr. Griffin reviews the effectiveness and waning immunity of RSV vaccines, and how Paxlovid may help reduce strokes. He emphasizes the significance of vaccination in alleviating long COVID symptoms and shares resources for those seeking help with long COVID. Finally, he highlights the need for better public engagement in health education.

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INSIGHT

CDC's Early Warning Loss

Defunding the CDC's Emerging Infectious Diseases journal reduces early warnings for pandemics.
This limits the US government's ability to respond rapidly and save lives during outbreaks.

INSIGHT

Bird Flu Awareness Gap

Most Americans are unaware bird flu can infect people and are reluctant to get vaccinated.
Public education must emphasize the serious risk and safety of vaccines for H5N1.

INSIGHT

Squirrels as Mpox Source

Fire-footed rope squirrels are the reservoir host for monkeypox virus in West Africa.
Human consumption of these squirrels likely explains some monkeypox outbreaks in the region.

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In his weekly clinical update, Dr. Griffin with Vincent Racaniello deplore the US’s withdrawal from the global health community for pandemic preparedness i.e. the universal avian flu vaccine, and undermining the use of routine childhood vaccinations for pertussis and measles, RFK’s autism registry, yellow fever outbreak in Colombia and world immunization week after discussing the squirrel as the reservoir host for mpox, before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections the WasterwaterScan dashboard, how immunity elicited by the RSV vaccine wanes in 3 years, if Paxlovid reduces stroke, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, if vaccination impacts long COVID and if long COVID were to become epidemic.

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Links for this episode

The American Public’s Disengagement With Highly Pathogenic Avian Influenza (HPAI): Considerations for Vaccination and Dietary Changes(American Public Health Association)
New agreement geared toward universal avian flu vaccine (CIDRAP)
Cambridge’s DIOSynVax and Singapore’s ACM Biolabs to advance pandemic-ready universal bird flu vaccine with international support (GlobeNewswire)
Bird flu continues to spread among live poultry markets after shut down order (CRAIN’S New York Business)
Fire-footed rope squirrels (Funisciurus pyrropus) are a reservoir host of monkeypox virus (Orthopoxvirus monkeypox)(Research Square)
It is a squirrel! An animal source of mpox emerges(Nature)
Whooping cough spikes, especially among unvaccinated teens (NBC News)
A February flu surge has arrived (NCB News)
Pertussis Cases by Year (1922-2022)(CDC: Whooping cough (pertussis)))
‘Fighting to breathe’: Whooping cough surges as vaccination rate falters (NBC News)
CDC cancels measles help for Texas schools amid staff layoffs (HealthDay)
Measles cases and outbreaks (CDC Rubeola)
Measles in Texas…. (Texas Health and Human Services)
Measles vaccine recommendations from NYP (jpg)
2025 Measles outbreak guidance (New Mexico Health)
Get the FACTS about measles (NY State Department of Health)
Measles (CDC Measles (Rubeola))
Measles vaccine (CDC Measles (Rubeola))
Presumptive evidence of measles immunity (CDC)
Contraindications and precautions to measles vaccination (CDC)
Measles (CDC Measles (Rubeola))
Measles (CDC: Measles Rubeola)
Adverse events associated with childhood vaccines: evidence bearing on causality (NLM)
Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America)
Deaths following vaccination: what does the evidence show (Vaccine)
RFK Jr.’s autism registry plan (Axios)
RFK Jr’s autism study collecting Americans’ private medical records (Guardian)
The public’s views on measles outbreaks and misinformation (KFF)
Colombia National Emergency: yellow fever cases (Gov.Co)
World Immunization Week: polio eradiation?(GPEI)
Influenza: Waste water scan for 11 pathogens (WastewaterSCan)
US respiratory virus activity (CDC Respiratory Illnesses)
Weekly surveillance report: clift notes (CDC FluView)
Respiratory virus activity levels (CDC Respiratory Illnesses)
200 children die from flu (CIDRAP)
Weekly surveillance report: clift notes (CDC FluView)
FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA)
RSV: Waste water scan for 11 pathogens (WastewaterSCan)
US respiratory virus activity (CDC Respiratory Illnesses)
RSV-Network (CDC Respiratory Syncytial virus Infection)
Trial shows waning efficacy of RSV vaccine across 3 seasons in older adults(CIDRAP)
Efficacy, safety, and immunogenicity of the AS01E-adjuvanted respiratory syncytial virus prefusion F protein vaccine (RSVPreF3 OA) (LANCET: Respiratory Medicine)
Waste water scan for 11 pathogens (WastewaterSCan)
COVID-19 deaths (CDC)
COVID-19 national and regional trends (CDC)
COVID-19 variant tracker (CDC)
SARS-CoV-2 genomes galore (Nextstrain)
Where to get pemgarda (Pemgarda)
EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
Infusion center (Prime Fusions)
CDC Quarantine guidelines (CDC)
NIH COVID-19 treatment guidelines (NIH)
Drug interaction checker (University of Liverpool)
Long-term stroke and mortality risk reduction associated with acute-phase paxlovid use in mild-to-moderate COVID-19(Journal of Medical Virology)
Infectious Disease Society guidelines for treatment and management (ID Society)
Molnupiravir safety and efficacy (JMV)
Convalescent plasma recommendation for immunocompromised (ID Society)
What to do when sick with a respiratory virus (CDC)
When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
Managing healthcare staffing shortages (CDC)
Steroids, dexamethasone at the right time (OFID)
Anticoagulation guidelines (hematology.org)
Daniel Griffin’s evidence based medical practices for long COVID (OFID)
Long COVID hotline (Columbia : Columbia University Irving Medical Center)
The answers: Long COVID
The effect of COVID-19 vaccination on the risk of persistent post–COVID-19 condition (JID)
ORCHESTRA Delphi consensus: diagnostic and therapeutic management of Post-COVID-19 condition in vulnerable populations (CMI Clinical Microbiology and Infection)
Political ideology and trust in scientists in the USA(Nature Human Behavior)
Leading long COVID researcher fears it could become a national epidemic (Spectrum News NY1)
Center for post COVID care (Mt. Sinai) Reaching out to US house representative
Letters read on TWiV 1212
Dr. Griffin’s COVID treatment summary (pdf)
Timestamps by Jolene Ramsey. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Content in this podcast should not be construed as medical advice.