Josh Hardman, founder of Psychedelic Alpha, discusses the challenges faced by the psychedelic industry including progress of decriminalisation, clinical trial milestones, and the potential evolution of the industry. They also touch on the current state of decriminalization in Oregon and Colorado, challenges in accessing regulated psilocybin, real-world evidence collection, drug development models, and the importance of in-person events in the psychedelic industry.
The psychedelic industry faces challenges regarding the reimbursement of psychedelic therapies and the need to demonstrate their value and cost-effectiveness to insurers and payers.
The potential of non-hallucinogenic psychedelics is being explored, highlighting the possibility of these molecules becoming a new class of psychiatric medicine.
The time it takes for payers to adopt reimbursement policies and establish logistical systems creates an advantage for second movers in the psychedelic industry.
Deep dives
Drug Science Podcast: The Evolution of Psychedelics
The podcast episode explores the evolution of the psychedelic sector, particularly in terms of recent policy reform. The guest, Josh Hardman, discusses the journey of psychedelic alpha, a web resource and newsletter focused on psychedelics. Initially starting as psilocybin alpha and later expanding to cover all psychedelics, the resource provides well-researched updates and analysis. Josh delves into the shift from a purely countercultural perspective of psychedelics to the emergence of a medical model. He discusses the potential benefits of having a medical model, such as reimbursement, making psychedelic therapy more accessible to a wider population. However, he also highlights the challenges in terms of cost-effectiveness and reimbursement from payers like health insurers. He emphasizes the importance of demonstrating the value and cost-effectiveness of psychedelic therapies. Additionally, he mentions the need for government engagement and support, as well as the importance of collecting real-world evidence and conducting bioequivalence studies for different psychedelic drugs.
The Challenges and Potential Solutions for Reimbursement
One of the main challenges discussed in the podcast is the issue of reimbursement for psychedelic therapies. The cost of therapy, including extensive hours of psychotherapy, can be significant, making it difficult for broad access to psychedelic treatments. Josh explains how insurers and payers are currently hesitant to cover the high costs associated with psychedelic therapy, especially in comparison to standard care. He advocates for a shift in perspective to consider the societal costs and benefits of psychedelic therapies, in addition to direct healthcare costs. He also suggests potential solutions, such as modifying the therapy approach, implementing group therapy models, and exploring the use of non-hallucinogenic psychedelics. He highlights the importance of demonstrating value and cost-effectiveness to insurers and payers, as well as the need for research and real-world evidence collection.
The Potential of Non-Hallucinogenic Psychedelics and Future Developments
The podcast also explores the potential of non-hallucinogenic psychedelics and the future developments in the field. Josh mentions the excitement around researching and understanding the therapeutic effects of non-hallucinogenic psychedelics, which were previously overlooked due to prohibition. He refers to ongoing trials and studies, such as those involving ketamine, to evaluate the efficacy and benefits of these alternative psychedelics. The discussion highlights the possibility of these molecules becoming a new class of psychiatric medicine, offering potential treatments for various conditions. The podcast also touches upon the importance of diversity in clinical trials and the need for broader research and funding in the field. Overall, the conversation provides insight into the evolving landscape of psychedelic therapies and the future possibilities of non-hallucinogenic psychedelics.
Logistics of Reimbursement and Patenting in Psychedelic Industry
One of the main challenges in the psychedelic industry is the time it takes for payers to adopt reimbursement policies and for logistics to be put in place. It can take years for the necessary systems to be established. This delay creates a potential advantage for second movers or for-profit companies who can leverage the groundwork laid by organizations like MAPS (Multidisciplinary Association for Psychedelic Studies). By the time these companies enter the market, the education of payers and the establishment of service delivery networks may already be in place, allowing them to expedite their progress.
The Challenges and Controversies of Patenting Psychedelics
Patenting psychedelics is a complex issue due to the nature of these substances. Naturally occurring substances like psilocybin mushrooms cannot be patented, but there are possibilities for patenting genetically edited or biosynthetic versions. Synthetic forms and methods of treatment can also be patented. However, there are concerns about the patenting of non-novel or non-innovative aspects of psychedelic drug development. The patent system primarily searches for published literature, which may not capture the rich history of psychedelic use. Challenging granted patents is costly and can exclude the public and indigenous communities from the process. There is also a case where a company filed patents for inventions already in use, raising concerns about patent trolling and potential hindrances to research and development.
In this episode, Josh Hardman, the founder of Psychedelic Alpha, explores the multitude of challenges currently being encountered by the psychedelic industry. He engages in discussions regarding the progress of decriminalisation and legalisation initiatives, upcoming clinical trial milestones, and delves into the current state and the potential evolution of the Psychedelic industry.