OncoPharm Tumor Lysis Syndrome
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Apr 4, 2024 Dive into the complexities of Tumor Lysis Syndrome, a crucial topic for oncology professionals. Discover the implications during chemotherapy and the importance of monitoring lab values to prevent severe complications. Explore effective prevention strategies for at-risk patients and learn about practical management techniques, including IV fluids and medications. This knowledge is vital for ensuring patient safety during treatment.
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Tumor Lysis Syndrome Basics
- Tumor Lysis Syndrome occurs when rapid tumor cell death releases intracellular contents that overwhelm the body.
- Key lab changes include hyperkalemia, hyperphosphatemia, hypocalcemia, hyperuricemia, and rising creatinine causing kidney injury and arrhythmias.
Identifying Patients At Risk
- Identify patients at risk by tumor type and burden, especially acute leukemias and aggressive lymphomas.
- Use white blood cell count and LDH as markers to assess tumor burden and TLS risk.
Fluid Management for TLS Prevention
- Start prevention with intravenous fluids using normal saline to dilute released electrolytes.
- Avoid sodium bicarbonate fluids as there's no evidence they prevent kidney injury better and may promote unwanted precipitations.