Plants of the Gods: Hallucinogens, Healing, Culture and Conservation podcast

Plants of the Gods: S1E9. Ergot, LSD and the Birth of Western Religions

Jan 27, 2021
The podcast explores the fascinating history of ergot, a fungus that once contaminated rye and triggered bizarre behaviors during the Salem Witch Trials. It delves into ergot's medicinal properties and its role in the synthesis of LSD by Albert Hofmann. The connections between hallucinogenic experiences and the formation of various Western religions are examined, alongside intriguing theories regarding ancient rites and psychoactive plants. Listeners are taken through a journey of how these elements contributed to mystical experiences throughout history.
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ANECDOTE

Cordyceps Led To Organ Transplant Breakthroughs

  • Mark Plotkin describes cordyceps' lifecycle and its astonishing manipulation of insect behavior.
  • He links the fungus to cyclosporine A, which enabled safe organ transplants by suppressing immune rejection.
INSIGHT

Fungi Are Underappreciated Drug Sources

  • Fungal metabolites have repeatedly given humanity major medicines like antibiotics and statins.
  • Ethnobotanical clues (e.g., Peti Peti) reveal fungi hidden inside plants with powerful alkaloids related to LSD.
INSIGHT

Ergot: Killer And Medicine

  • Ergot infects rye and packs alkaloids that can cause hallucinations, gangrene, uterine contractions, or death.
  • The same chemistry yields useful drugs like ergometrine for postpartum bleeding and ergotamine for migraines.
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