Matt Maiocco and Jennifer Lee Chan analyze how the 49ers’ defense can move forward after losing Javon Hargrave for the season and explain why it’s not time to panic despite the mounting injuries. Also, Matt sits down with Greg Papa to discuss how the Patriots could attack the 49ers on Sunday, and checks in with NBC Sports Boston’s Tom Curran for a full New England scouting report.

6:00 How 49ers can move forward without Hargrave

18:00 Can Brock Purdy, Jauan Jennings replicate connection vs. Patriots

24:45 Why it's not time for 49ers to panic

32:30 Greg Papa analyzes 49ers' defense

39:45 Papa details how New England could attack 49ers

45:45 Tom Curran discusses Purdy's performance vs. Rams

50:45 Curran provides Patriots scouting report

54:45 Predictions for 49ers-Patriots game