Multiple myeloma mid-year progress with Dr. Paul Richardson of Dana Farber
Sep 22, 2023
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Dr. Paul Richardson from Dana Farber discusses fast-moving myeloma research, including bispecific antibodies, CAR T trials, sequencing preferences, BCMA therapies, MRD advances, and blood-based testing. Updates on new therapy targets, clinical trial endpoints, and more exciting findings in the field.
Tailoring treatment to individual patients is crucial in myeloma therapy, especially with quadruplet regimens like DaraTumorMap.
Personalized care in myeloma focuses on high-risk patients and integrates MRD testing for treatment decisions.
Targeting BCMA in myeloma treatment, particularly with CAR-T and bi-specific T-cell engagers, shows promising outcomes and reshapes treatment strategies.
Deep dives
Advancing Myeloma Treatment Through Innovation
In the podcast, Dr. Paul Richardson discusses the pivotal role of innovation in advancing multiple myeloma treatment. He emphasizes the importance of tailoring treatment to individual patients and highlights the significance of quadruplet therapies with drugs like DaraTumorMap. Dr. Richardson underscores the evolving landscape of myeloma treatment, particularly focusing on how new drug approvals and clinical trials are shaping more effective therapeutic approaches.
Enhancing Personalized Care and Treatment Strategies
Dr. Richardson delves into the concept of personalized care in multiple myeloma, especially in high-risk patients. He explores the nuances of risk factors such as 17P deletion and translocation 4;14, shedding light on tailored treatment approaches using agents like Selenexor and Bortezomib. Moreover, he touches upon the integration of minimal residual disease (MRD) testing in decision-making for treatment strategies in newly diagnosed patients and relapse scenarios.
BCMA as a Target and Revolutionizing Early Relapse Approaches
The podcast scrutinizes the efficacy of targeting B-cell maturation antigen (BCMA) in multiple myeloma treatment. Dr. Richardson explains why BCMA is an effective target due to its universal expression in myeloma cells. He also discusses the rise of BCMA-directed therapies like CAR-T and bi-specific T-cell engagers in early relapse scenarios, showcasing promising outcomes and revolutionizing treatment paradigms. The discussion further revolves around the implications of BCMA targeting in personalized care, optimal patient selection, and future treatment algorithms.
Advancements in Outpatient Treatment Strategies
Advancements in outpatient treatment approaches have alleviated the burden on patients, emphasizing the importance of off-the-shelf constructs and outpatient care. The availability of outpatient strategies, including infusional and non-hospitalization therapies, has improved access to care for communities, especially vulnerable ones. With a focus on outpatient settings and treatment initiation without hospitalization, the shift towards outpatient care is enhancing patient experience and treatment accessibility.
Innovative Oral Agents and Sequential Treatment Planning
Innovative oral agents like Melflufen and mesidemide are showing promise in improving treatment outcomes for multiple myeloma patients. These oral agents act as powerful degraders and immune system activators, leading to significant responses. Additionally, the strategic sequencing of treatments, such as using TAC573 and Balantamid in treatment regimens, offers a personalized and effective approach to managing the disease, ensuring patient safety and treatment efficacy across different stages of the disease.
Dr. Paul Richardson of the Dana Farber Cancer Institute shares a mid-year myeloma review of ASCO, EHA and upcoming International Myeloma Society findings of the fast-moving research being performed in myeloma. Updates will include the expanding world of bispecific antibodies that include one FDA-approved drug and anticipated approvals for two new bispecific antibodies. He will also discuss exciting results from CAR T cinical trials, CAR T newcomers, sequencing preferences, BCMA targeted therapies, new therapy targets in myeloma, MRD advances, blood-based testing, clinical trials end points and more.
Thanks to our episode sponsor, Karyopharm.
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