MCAT Metabolism Part 3: ETC & Oxidative Phosphorylation Explained

In Episode 27, we wrap up our Metabolism series by diving into one of the most testable—and often misunderstood—topics on the MCAT: The Electron Transport Chain (ETC) and Oxidative Phosphorylation.

We cover everything you need to know for MCAT success:

🔬 What You’ll Learn:

Where ETC happens: The inner mitochondrial membrane

Complex I vs. Complex II: NADH vs. FADH₂

The secret identity of SDH (succinate dehydrogenase)

How proton gradients drive ATP production

Why uncouplers like 2,4-DNP are dangerous

Why cyanide is lethal (hint: Complex IV)

Final ATP yields from NADH and FADH₂ (30–36 total!)

📚 Pro Tip: Make sure to review Redox and Thermodynamics before watching this episode.

Next up: We'll break down alternative fuel sources—like proteins, fats, and ketones—in our upcoming non-glucose metabolism episode!

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