LDL-Cholesterol is USELESS! Measure this Instead: ApoB
Apr 13, 2023
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Learn why LDL cholesterol measurements may not accurately assess cardiovascular risk and why focusing on ApoB levels is more crucial. Discover the importance of optimal ApoB levels, the impact of oxidative stress on atherosclerosis risk, and the ineffectiveness of standard LDL measurements in predicting heart disease risk.
Apolipoprotein B testing provides a more accurate assessment of cardiometabolic disease risk than standard LDL cholesterol measurements.
Apolipoprotein B plays a direct causal role in the development of atherosclerosis, emphasizing the importance of measuring Apolipoprotein B levels.
Deep dives
Transition from LDL Cholesterol to Apolipoprotein B Testing
The podcast highlights the shift in focus from traditional LDL cholesterol measurements to the more accurate Apolipoprotein B testing. It explains that LDL cholesterol measurements are now seen as inaccurate estimates, especially in individuals striving for metabolic health. By emphasizing the significance of Apolipoprotein B over LDL cholesterol, the podcast advocates for a more precise understanding of atherogenic lipoprotein particles circulating in the body.
Understanding Apolipoprotein B and Atherosclerosis
The discussion delves into the importance of Apolipoprotein B in relation to atherosclerosis. It reveals that Apolipoprotein B plays a direct causal role in the development of atherosclerosis, leading to cardiovascular events. By examining the impact of Apolipoprotein B on atherogenic lipoprotein particles, the podcast underscores the need to measure Apolipoprotein B levels for a more comprehensive cardiovascular risk assessment.
The podcast challenges the conventional focus on LDL cholesterol alone in cardiovascular risk assessment. It argues that relying solely on LDL cholesterol measurements can overlook crucial factors like high triglycerides and low HDL cholesterol levels, especially in individuals with diabetes and metabolic syndrome. By advocating for Apolipoprotein B testing alongside traditional lipid panels, the podcast urges a more comprehensive approach to evaluating cardiovascular health and risk factors.
Emerging data suggests using is ApoB as well as the ApoB/ ApoA1 ratio more accurately assess cardiometabolic disease risk than standard LDL-cholesterol testing.
0:00 Intro 0:03 Standard LDL cholesterol measurements are estimates. 0:15 Every atherogenic lipoprotein has one ApoB100. 1:10 ApoB is causally related to atherosclerosis. 2:08 Optimal ApoB is under 60. 4:05 LDL measurements do not correlate to risk. 6:40 Biomarkers of oxidative stress are linked with risk of atherosclerosis. 7:30 Focus on ApoB levels and the ratio or ApoB to apoA1. 8:50 Many people who die of heart disease have low or normal LDL cholesterol. 10:15 Look for biomarker patterns. 11:30 Atherogenic cholesterol is made by your liver. 12:43 Prevent oxidation and do not ingest oxidated seed oils. 15:30 Triglycerides skew LDL measures.
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