It’s flu season: Why do we need a shot every year? And should we be worried about the new avian influenza strain?
Sep 20, 2023
auto_awesome
This podcast explores the annual flu vaccine and the need for it, including an in-depth discussion on influenza virus types, past pandemics, and the challenges of developing vaccines for birds. It also delves into the potential of a universal vaccine and the advancements in technology to combat global pandemics. The podcast touches on the risks of DNA synthesis and the ethical controversies surrounding gene editing.
29:35
AI Summary
AI Chapters
Episode notes
auto_awesome
Podcast summary created with Snipd AI
Quick takeaways
The yearly flu shot is necessary due to the constantly changing strains of influenza viruses and occasional mismatches between the vaccine and the actual virus, resulting in reduced efficacy.
Avian influenza, especially the highly pathogenic H5N1 strain, poses a significant threat to bird populations, and targeted vaccinations in small populations like animals in zoos or endangered species are critical prevention strategies.
Deep dives
The Importance of Getting the Flu Shot Every Year
Flu season is a recurring threat that leads to severe illness and death globally. Every year, people are advised to get their flu shot to protect themselves. Influenza viruses, specifically type A, are responsible for yearly epidemics and have the potential to cause pandemics. Type A influenza viruses have different subtypes of hemagglutinin and neuraminidase proteins, such as the notorious H1N1 strain. Scientists have been expecting the next big pandemic to be caused by an influenza virus rather than a coronavirus. The creation of a universal influenza vaccine is a major focus in research, striving to offer protection against multiple strains of flu. Despite the success and power of mRNA vaccines, other types of vaccines, such as recombinant protein and live viral vector vaccines, continue to be researched and developed alongside them.
The Challenges of Vaccinating Birds for Avian Influenza
Avian influenza, especially the highly pathogenic H5N1 strain, poses a significant threat to bird populations. Vaccinating birds against avian influenza is possible, but faces challenges such as the logistical hurdle of administering shots to millions of birds and potential trade restrictions. The current focus is on targeted vaccinations in small populations like animals in zoos or endangered species. The detection of H5N1 in US commercial poultry and wild birds led to major impacts on wild bird populations, including bald eagles and California condors. Bird vaccinations serve as a critical prevention strategy, especially in small-scale operations and backyard flocks that lack the stringent biosecurity measures of commercial flocks.
Understanding the Annual Flu Shot and the Quest for a Universal Vaccine
The yearly flu shot is necessary due to the constantly changing strains of influenza viruses. The World Health Organization predicts and recommends the strains to include in each year's flu vaccine, and most of the time, the recommendations align with the circulating strains. However, there are occasional mismatches between the vaccine and the actual virus, resulting in reduced efficacy. Researchers are also actively working on developing a universal influenza vaccine that can protect against numerous strains, potentially even including avian flu. This universal vaccine aims to stimulate the innate immune system and provide immediate protection in case of future pandemics before specific vaccines can be developed. While mRNA vaccines show promise, other vaccine technologies like recombinant protein and adjuvanted vaccines continue to be explored to offer a diverse range of options.
Why do we need an influenza vaccine every year when there are many vaccines we only need to get once every few decades? In this episode, Deboki and Sam kick things off by covering the different strains of influenza that are most likely to cause, or already caused, pandemics. They also chat with experts about the new, more deadly strain of avian influenza — H5N1 — that has been making its rounds in the United States since January 2022, leading to the deaths of over 58 million birds, not just impacting farms and egg prices but wild bird populations.
Sam and Deboki also delve into flu strain predictions each year — which dictate what’s in the vaccine, and aren’t always accurate — and the promise of a universal vaccine for not just flu but all pathogens, which could be crucial for saving lives early in a future pandemic. Links to the Tiny Show & Tell stories are here and here. Pick up a Tiny Matters mug here! All Tiny Matters transcripts are available here.
Get the Snipd podcast app
Unlock the knowledge in podcasts with the podcast player of the future.
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode
Save any moment
Hear something you like? Tap your headphones to save it with AI-generated key takeaways
Share & Export
Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode