Tiny Matters New male contraceptives could be here soon. What took so long?
Oct 29, 2025
Join John Amory, a distinguished professor of medicine specializing in family planning, as he dives into the world of male contraceptives. He discusses the pressing need for more options, revealing the current landscape dominated by just three methods. The fascinating NEST-T trial is highlighted, showcasing a promising hormonal gel that could soon revolutionize male contraception. Amory also explores biological hurdles and insights, making a compelling case for why men need more equitable options in family planning.
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High Demand For NEST-T Trial
- John Reynolds Wright described overwhelming volunteer interest in the NEST-T trial, with 1,500 contacts at the Edinburgh site alone.
- The study team worked late answering calls because people were eager to enroll in the male contraceptive trial.
Vasectomy Is Highly Effective Yet Permanent
- Vasectomy is roughly 99.95% effective but is intended as permanent contraception.
- Sperm continue to be produced and are reabsorbed or lead to anti-sperm antibodies after vasectomy.
Condom Efficacy Hinges On Use
- Condom failure rates depend heavily on real-world use, not lab tests.
- Perfect condom use in trials yields about a 2% failure rate versus 13–18% in surveys.