Tasty Morsels of Critical Care Tasty Morsels of Critical Care 001 | Thrombotic Thrombocytopaenic Purpura
Oct 28, 2020
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TTP Is A Type Of MAHA
- Thrombotic thrombocytopenic purpura (TTP) is a form of thrombotic microangiopathic haemolytic anaemia (MAHA).
- Key lab clue is schistocytes on the blood film, prompting consideration of TTP in ICU patients.
ADAMTS13 Loss Drives Platelet Microthrombi
- ADAMTS13 is the protease that cleaves large vWF multimers and its deficiency causes platelet-rich microthrombi.
- Loss of ADAMTS13 leads to platelet aggregation and small-vessel occlusion characteristic of TTP.
Stress Triggers And Why Plasma Helps
- TTP is often triggered by stressors such as surgery, trauma, or infection that precipitate autoantibody formation.
- Plasma replacement both supplies ADAMTS13 and reduces bleeding risk by restoring factors.