Nice Genes!
Three Blind Mice
Apr 9, 2024
Scientists have reversed a mutation causing blindness in mice using gene editing technology. Research in Wuhan, China shows promise in restoring vision. Mice with retinitis pigmentosa benefited from gene editing, offering hope for human treatment.
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Quick takeaways
- CRISPR gene editing in mice reversed blindness caused by retinitis pigmentosa by correcting a gene mutation encoding enzyme PDE6B.
- Successful gene editing in mice paves the way for potential human trials to reverse retinitis pigmentosa, offering hope for vision restoration.
Deep dives
Gene Editing Reverses Blindness in Mice
Researchers in Wuhan, China utilized CRISPR gene editing to reverse blindness in mice with retinitis pigmentosa by correcting a gene mutation that encodes the enzyme PDE6B. This gene editing technique, named PASPRI, prevented the death of rods and cone photoreceptors in the eyes, essential for vision in low light and color differentiation. Retinitis pigmentosa, a group of rare eye diseases affecting the retina, causes a gradual breakdown of cells, leading to vision loss. Testing involved observing mice navigate a maze and react to visual stimuli, showing promising results for potential future human trials.
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