Mast Cell Matters: Deep dives on MCAS with Tania Dempsey, MD - Presented by The POTScast Psychiatric Manifestations of MCAS with Dr. Janet Settle
Dec 5, 2023
Dr. Janet Settle, a forward-thinking psychiatrist, discusses the pivotal role of mast cell activation in mental health issues like anxiety and bipolar disorder type II. She emphasizes an integrated treatment approach that addresses both psychiatric symptoms and mast cell stability. The conversation explores the often-overlooked connection between histamine levels and brain function, plus the benefits of brain retraining and emotional regulation techniques for those experiencing MCAS. Settle advocates for a holistic understanding of mental health that includes trauma and personal health signals.
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MCAS Causes Episodic Psychiatric Symptoms
- Psychiatric symptoms like mood swings, panic attacks, brain fog, and obsessive anxiety can be episodic and linked to mast cell activation.
- Suicidal ideation and psychosis may also be manifestations of mast cell-related neuroinflammation.
Mast Cells Impact Brain Functions
- Mast cells exist at the blood-brain barrier and in brain tissue, releasing histamine and other signals during perceived threats.
- Histamine-producing neurons in the hypothalamus participate in fear, mood, and autonomic regulation, linked to anxiety and depression.
Try Brain Retraining Programs
- Use brain retraining programs like Gupta or Dynamic Neural Retraining System to control physiology through emotional regulation.
- Start with mindful self-compassion for those too sensitive for intensive retraining methods.