Mast Cell Matters: Deep dives on MCAS with Tania Dempsey, MD - Presented by The POTScast Diagnosis & Treatment of MCAS with Dr. Tania Dempsey
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Nov 8, 2023 Dr. Dempsey dives into the complexities of diagnosing Mast Cell Activation Syndrome (MCAS), emphasizing its multi-system effects. She discusses the importance of addressing comorbidities like POTS. The podcast highlights various treatment options, including Montelukast and Zolair, while stressing the significance of personalized care. Real-life challenges such as long wait times and the intricacies of symptom management are explored, empowering patients with knowledge about their journeys in managing MCAS.
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MCAS Multisystemic Symptom Insight
- MCAS typically affects multiple systems with diverse symptoms due to mast cells' widespread presence.
- Diagnosis requires symptoms in two or more body systems plus at least one of three themes: allergic, inflammatory, or abnormal growth.
MCAS, POTS, and Anxiety Link
- POTS is often linked to mast cell activation, with many POTS patients also having MCAS.
- Anxiety in MCAS can stem from brain inflammation caused by mast cell mediator release affecting neural signaling.
Comprehensive MCAS Diagnosis Approach
- Take a thorough medical history and perform physical exams, including skin scratch test and orthostatic testing for MCAS.
- Rule out other conditions systematically while looking for multisystem symptoms and markers of mast cell dysfunction.