Challenges and opportunities of combining RWE and RCT data

Join our discussion today as Thomas and I talk about this.

Key references:

1. Debray TPA, Moons KGM, van Valkenhoef G, Efthimiou O, Hummel N, Groenwold RHH, et al. Get real in individual participant data (IPD) meta-analysis: a review of the methodology. Res Synth Methods. 2015 Aug 19;6:239–309.
2. Debray TPA, Riley R, Rovers M, Reitsma JB, Moons K, on behalf of the Cochrane IPD Meta-analysis Methods group. Individual Participant Data (IPD) Meta- analyses of Diagnostic and Prognostic Modeling Studies: Guidance on Their Use. PLoS Med. 2015;12(10):e1001886.
3. Debray TP, Schuit E, Efthimiou O, Reitsma JB, Ioannidis JP, Salanti G, et al. An overview of methods for network meta-analysis using individual participant data: when do benefits arise? Stat Methods Med Res. 2018;7(5):1351–64.
4. Nguyen T-L, Debray TPA. The use of prognostic scores for causal inference with general treatment regimes. Stat Med. 2019 Jan 16;38:2013–29.
5. Sarri G, Patorno E, Yuan H, Guo J (Jeff), Bennett D, Wen X, et al. Framework for the synthesis of non-randomised studies and randomised controlled trials: a guidance on conducting a systematic review and meta-analysis for healthcare decision making. BMJ EBM. 2020 Dec 9;bmjebm-2020-111493.

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