#51 - Bryan Johnson

Mar 21, 2024

This podcast features Bryan Johnson, known for his metabolic health achievements, longevity projects, and investments in technology. He shares insights on gene therapy, reducing aging, and the future of humanity. Johnson's endeavors include Project Blueprint, Rejuvenation Olympics, and OS Fund, showcasing a unique blend of innovation and impact-driven initiatives.

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ANECDOTE

Braintree and John Adams

Bryan Johnson named his company Braintree after John Adams' birthplace.
Reading Adams' biography showed him how history is constructed and not always as perceived.

INSIGHT

Zeroth-Principle Thinking

Zeroth-principle thinking involves working with unknown unknowns, like Einstein's theory of relativity.
It differs from first-principle thinking, which builds upon existing knowledge.

INSIGHT

Project Blueprint's Origin

Project Blueprint resulted from a thought experiment about what the 25th century would value from the 21st.
It aims to identify the 0.01% of actions today that will truly matter in the long term.

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Bryan Johnson is the world's most measured human. Johnson sold his company, Braintree Venmo, to PayPal for $800m in 2013. Through his Project Blueprint, Johnson has achieved metabolic health equal to the top 1.5% of 18 year olds, inflammation 66% lower than the average 10 year old, and reduced his speed of aging by the equivalent of 31 years.

Johnson freely shares his protocols and data publicly for everyone to use. Project Blueprint, is an endeavor to achieve humanity and earth scale cooperation starting within Self.

In 2023, Johnson launched Rejuvenation Olympics, a leaderboard assessing one's speed of aging using DNA methylation. Of the 1,750 people who have been using this state-of-the-art aging algorithm to track their progress longitudinally, Johnson ranks #1 in speed of age reduction.

Johnson is also the founder & CEO of Kernel, creator of the world’s first mainstream non-invasive neuroimaging system; and OS Fund, where he invested $100M in the predictable engineering of atoms, molecules, and organisms into companies now collectively valued over $6B. He is an outdoor adventure enthusiast, pilot, and author of children’s books, Code 7 and The Proto Project.

00:00 - Intro 3:45 - Biographies 5:03 - Zeroth Principles Thinking and Genius 6:24 - Vision for Blueprint: A 25th Century Perspective 7:50 - Blueprint, Entropy Reduction and Planet Earth 9:23 - Impact of Blueprint 10:47 - Gene Therapy and Breaking Through the Longevity Ceiling 12:06 - Living Longer and Compounding Gains 13:31 - Bryan’s Relationship With Time 14:07 - Measuring Biological vs Chronological Age 15:05 - Encouraging Adoption, Dashboards for Society and Learning How to Swim 17:49 - Enriching vs Degrading Life and the Inevitability of Computational Intelligence 21:03 - Living Forever 22:19 - Knee-Jerk Reactions 26:03 - Free Will 28:12 - Social Drivers and Early Adopters of Blueprint 30:08 - Future of Engineering Atoms, Molecules and Organisms 32:43 - Critical Questions from Longer Lifespans 33:58 - Kernel and the Future of Brain-Computer Interfaces 36:28 - Ketamine 37:47 - Storytelling, Quantifying Reality and the Extent of the Algorithm 40:03 - OS Fund, Foundational Technologies and Architecting Reality 43:38 - Trust and God Shaped Holes 46:55 - Wealth, Effectuating Change and Competing for Legacy 48:23 - What Else Would Bryan Work On? 49:25 - What Should More People be Thinking About?

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