The Radiopaedia Reading Room Podcast 48. Readful! Glioblastoma with Frank Gaillard
May 27, 2024
Expert radiologist Frank Gaillard discusses the evolving definitions and classifications of IDH-wildtype glioblastomas, highlighting the importance of molecular parameters in diagnosis. The podcast explores the challenges in imaging differentiation, advancements in MRI techniques for treatment monitoring, and post-operative follow-up protocols. Banter about supporting Radiopaedia and humorous lunch/dinner discussions add a light touch to the informative episode.
AI Snips
Chapters
Transcript
Episode notes
GBM Definition Change
- Glioblastomas are now defined by IDH wild-type molecular status, not necrosis.
- Astrocytomas with necrosis remain astrocytomas, grade 4, even with necrosis.
Outdated Terminology
- Avoid using the term "multiforme" for glioblastoma.
- Using it makes you sound outdated.
IDH Mutation Effects
- IDH mutations in gliomas cause a gain of function, producing 2HG.
- 2HG mimics glutamate, increasing seizure risk, and it's cytotoxic, slowing growth.