Emergency Medicine Board Bombs
192. Schistocytes and Schmears
Oct 2, 2023
Discussion on a rare but life-threatening diagnosis, Thrombotic Thrombocytopenic Purpura (TTP), emphasizing its clinical manifestations, diagnostic criteria, and treatment options. The hosts also address common misconceptions about TTP and highlight the importance of accurate rash description in the diagnosis of the condition.
22:02
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Quick takeaways
- Thrombotic Thrombocytopenic Purpura (TTP) is a rare but life-threatening disease characterized by low platelet count, anemia, and widespread clotting in small blood vessels, emphasizing the need for prompt recognition and treatment.
- The diagnosis of TTP relies on specific laboratory findings, such as the presence of schistocytes on a blood smear and a platelet count of less than 20,000, highlighting the importance of these diagnostic markers.
Deep dives
Thrombotic Thrombocytopenic Purpura (TTP) - A Life-Threatening Condition
In this podcast episode, the main focus is on the rare disease Thrombotic Thrombocytopenic Purpura (TTP), which is characterized by low platelet count, anemia, and widespread clotting in small blood vessels. The podcast emphasizes the importance of recognizing TTP as a medical emergency due to its high mortality rate without treatment. It mentions common triggers for TTP, such as infections and autoimmune conditions like lupus. It also highlights the need for broad-spectrum antibiotics, although it does not treat TTP itself. The primary treatment for TTP is plasma exchange, and the podcast cautions against giving platelet transfusions.
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