Lysergic acid diethylamide (LSD) is one of fungi’s most well known chemical analogues. Today we bring you a leading scientist, Dr. David Nichols who speaks to the history, chemistry, legality and so much more of this notable compound.
Topics covered:
- David Nichol’s career pursuing psychedelic pharmacology
- Patent litigation, especially with psychedelic constituents
- Lab testing for new psychedelic analogues in rats
- Bureaucracy of working with Schedule I substances
- How to synthesize LSD
- LSD’s physical characteristics, structure and fluorescence
- What happens to the LSD molecule when you adjust minute aspects, and what that tells us about itself
- Structural similarities and differences in an array of psychedelic molecules / chemical ‘templates’ for psychoactive compounds
- Neuro-mechanics of LSD and other entheogenic compounds
- Evolution and function of serotonin receptors
- HPPD: Hallucinogen Persisting Perception Disorder
- Trepanation: how does it affect neurochemistry, if at all?
- NBOMes (N-benzyl methoxy): What is it and how does it work?
- Metabolizing LSD and related compounds
- Chirality in psychedelics, especially LSD
- Listener questions
Show notes:
Hamilton’s Pharmacopeia feat. Dr. Nichols: https://www.youtube.com/watch?v=7N4VoqeuK3s
Hallucinogens (2004) : https://pubmed.ncbi.nlm.nih.gov/14761703/
DEA 222 - https://dehs.umn.edu/using-dea-form-222-order-controlled-substances
Mapping the Mind Talk: https://www.youtube.com/watch?v=6hfsIbib_50
MAPS Talk: https://www.youtube.com/watch?v=TxjCSKMbZBA
Telluride Keynote presentation: https://www.youtube.com/watch?v=RlDCM5JQzRk
Leo Perutz & the Mystery of St Peter’s Snow: https://www.tandfonline.com/doi/abs/10.2752/175169713X13589680082172
Trepanation articles & video: https://lostmediawiki.com/Heartbeat_in_the_Brain_(partially_found_Amanda_Fielding_trepanation_documentary;_1970)
Downloadable literature: https://drive.google.com/drive/folders/14N9VdXGFlLvjnShYRH2MRurNi54a77Ig?usp=sharing
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