Nate Tice is joined by Charles McDonald as they look ahead to Week 10 of the NFL season by deep diving on the biggest matchup of the weekend and giving one thing to watch in every single game.

Nate and Charles start with the Detroit Lions taking on the Houston Texans on Sunday night, as it's hard to see how Houston can stop the Lions from dominating both sides of the ball, but Nate points out that having Joe Mixon on the field makes a big difference. Both predict a Lions win, but there is a scenario where C.J. Stroud can play enough hero ball to keep it close.

Next, Nate and Charles give one thing to watch for every Week 10 matchup as they get into the one interesting matchup in the Munich game, a big rookie quarterback battle, the Pope sending encouraging words to the New Orleans Saints, how Bo Nix can beat the Spagnuolo defense, Jayden Daniels vs. Mike Tomlin, how Aaron Rodgers will attack the Arizona defense and much more.

Nate finishes up with a mailbag question on the Los Angeles Chargers run game as he takes a closer look at the offense in its first year under Jim Harbaugh.