Critical Care Scenarios Episode 71: Transplant medications with Olivia Philippart
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Feb 28, 2024 Transplant clinical pharmacist Olivia Philippart discusses managing infections in transplant patients, timing of transplant medication effects, adjusting medications for severe infections, pharmacokinetics in critically ill patients, drug administration nuances, and considerations for steroid use in transplant patients.
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Hold Mycophenolate in Sepsis
- Hold or dose-reduce mycophenolate mofetil in septic patients to help fight infection.
- Be cautious with immunosuppressive drugs during acute infections in transplant patients.
Variable Immunosuppression Risk
- Immunosuppression level varies by time from transplant and drugs used.
- Patients are primarily at increased risk for community pathogens and viral reactivations like CMV.
Timing Shapes Infection Risks
- Early post-transplant patients are prone to nosocomial and surgical site infections.
- Later transplant patients face usual community infections, adjusted by their exposures and history.