High Intensity Health with Mike Mutzel, MS

Lower Cholesterol, Higher Odds of Death New Studies Find

Jan 23, 2024

This podcast explores the paradox of cholesterol, discussing how high cholesterol can be protective against mortality. It highlights the different correlations of cholesterol levels in middle-aged men and older individuals. The composition of cholesterol particles and their relationship to cardiovascular disease are also explored, emphasizing the importance of testing the APO B to A1 ratio. Additionally, the podcast challenges the oversimplification of the relationship between cholesterol and cancer, and encourages informed decision-making based on HDL to triglyceride ratios and remnant lipoproteins.

11:09

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Quick takeaways

Higher blood cholesterol levels in older adults are associated with better protection against death from cardiovascular disease and cancer.

Low cholesterol levels are linked to poor prognosis of cancer and highlight the complex relationship between cholesterol, metabolic health, and overall well-being.

Deep dives

The Cholesterol Paradox: Higher Blood Cholesterol Associated with Better Protection Against Cardiovascular Disease and Cancer in Older Adults

Contrary to the traditional belief that high cholesterol is harmful, several studies have found a correlation between higher blood cholesterol and better protection against death from cardiovascular disease and cancer in older adults. A recent study titled 'Cholesterol Paradox in Community Living Adults' reinforces this correlation and emphasizes the importance of questioning why clinical guidelines recommend lower cholesterol levels. While high cholesterol may be a risk factor for middle-aged men, there is not a strong correlation between high cholesterol and cardiovascular disease in both older men and women. Furthermore, low cholesterol levels have been associated with poor prognosis of cancer, indicating a complex relationship between cholesterol, metabolic health, and overall well-being.

Introduction

2min

The Association Between Cholesterol and Cardiovascular Disease

4min

Understanding Cholesterol Particles and Their Relationship to Cardiovascular Disease and Cancer

2min

The Complexity of Cholesterol and its Association with Health and Longevity

3min

While high levels of cholesterol are often associated with an increased risk of cardiovascular disease, the paradox arises when studies reveal unexpected relationships between low cholesterol levels and certain health issues.

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References:

Wang, S.-S. et al. Cholesterol paradox in the community-living old adults: is higher better? J. Geriatr. Cardiol. 20, 837–844 (2023).

Murata, S. et al. Blood biomarker profiles and exceptional longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort. GeroScience 1–10 (2023) doi:10.1007/s11357-023-00936-w.

Time Stamps:

00:00 High cholesterol, as you age, is protective.

01:10 Higher HDL and higher total cholesterol is associated with greater longevity and reduction in death from cardiovascular disease.

02:00 Middle aged men have a risk from high LDL and high total cholesterol.

02:25 Low Cholesterol is associated with mortality from stroke, heart disease and cancer.

05:40 Your LDL goes up as you become more metabolically healthy.

05:50 Triglycerides enrich cholesterol particles in the insulin resistant

06:15 Test your ApoB to A1 ratio. HDL and triglycerides should be close to 1:1.

07:00 Low cholesterol is a risk factor for poor prognosis for cancer.

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High Intensity Health with Mike Mutzel, MS

Lower Cholesterol, Higher Odds of Death New Studies Find

Podcast summary created with Snipd AI

Quick takeaways

Deep dives

The Cholesterol Paradox: Higher Blood Cholesterol Associated with Better Protection Against Cardiovascular Disease and Cancer in Older Adults

The Inadequacy of Total Cholesterol Measurements for Assessing Cardiovascular Risk

A Holistic Perspective on Cholesterol: The Need to Consider the Entire Picture

Remember Everything You Learn from Podcasts