324: Genentech's cancer pivot, Pfizer's sickle cell withdrawal, and a new schizophrenia drug
Sep 26, 2024
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Jonathan Wosen, a seasoned colleague in oncology research, shares insights on the latest shifts in the life sciences. The conversation highlights Genentech's decision to close its cancer immunology division and the reaction from the biotech community. Wosen also discusses Pfizer’s withdrawal of its sickle cell treatment and the implications for future drug approvals. Additionally, they explore the promising prospects of a new schizophrenia drug set to be approved, emphasizing the urgent need for innovative therapies in mental health.
Pfizer's withdrawal of its sickle cell drug highlights critical safety concerns and reflects the industry's ongoing challenges with accelerated approval processes.
The anticipated approval of Bristol-Myers Squibb's CAR XT for schizophrenia signifies a major breakthrough in treatment options for this complex disorder.
Deep dives
Pfizer's Withdrawal of Sickle Cell Drug
Pfizer's decision to withdraw its sickle cell treatment, Ox-Bryta, from global markets marks a significant development in the life sciences. Approved in both the U.S. and Europe, this drug was expected to provide relief for patients but raised safety concerns after recent findings indicated a troubling imbalance of adverse events, including fatalities. The withdrawal has raised questions about Pfizer's due diligence during its acquisition of Global Blood Therapeutics, highlighting the need for thorough evaluation of accelerated approval drugs. This surprising move reflects broader concerns within the pharmaceutical industry regarding the efficacy and safety profiles of treatments previously deemed promising.
Advancements in Schizophrenia Treatment
The anticipated approval of a new schizophrenia treatment by Bristol-Myers Squibb represents a promising advancement in addressing a severe neuropsychiatric disorder. This new drug, known scientifically as CAR XT, significantly reduces the frequency of psychotic episodes with a more favorable side effect profile compared to existing therapies. Its development involved innovative research strategies that combined insights from prior treatments, thereby mitigating intolerable side effects observed in earlier iterations. This breakthrough is particularly crucial as patients with schizophrenia have historically faced a scarcity of new therapeutic options for decades.
Changes in Cancer Immunotherapy Research
Genentech's closure of its cancer immunology group and the departure of its research chief reflect shifting dynamics within the cancer immunotherapy landscape. The move has left employees feeling a mix of nostalgia and concern, as the group was instrumental in popularizing immunotherapy approaches but struggled to find new blockbuster targets after initial successes. This shift may indicate a broader trend towards a more conservative stance in drug development, particularly in light of the difficulties faced by the industry in replicating the success of established drugs like Keytruda. The future focus for Genentech may pivot towards outsourcing research and acquiring promising assets from external companies.
Our colleague Jonathan Wosen joins us to discuss the recent setbacks and wins in oncology R&D, including Genentech's decision to shut down its cancer immunology group, and the global ambitions of Akeso, the Chinese biotech behind Summit Therapeutics’ recent positive results. We also chat about the latest news in the life sciences, including Pfizer’s sudden announcement to pull its sickle cell drug and the imminent approval of Bristol Myers Squibb’s schizophrenia treatment.
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