This podcast discusses the implications of conveying patients with ROSC from cardiac arrest centers, timing of surgery for acute appendicitis, and the use of bicarbonate, calcium, and magnesium in cardiac arrest. It explores the findings of studies and the importance of well-designed prospective trials for more definitive evidence.
Patients with a presumed cardiac origin cardiac arrest, without ST segment elevation, showed no difference in all-cause mortality at 30 days whether taken to a cardiac arrest center or a local emergency department.
Delaying surgery for up to 24 hours for patients with acute appendicitis does not increase the risk of complications like perforation.
Deep dives
Expedited Transfer to Cardiac Arrest Center for Non-ST Segment Elevation Out of Hospital Cardiac Arrest
A randomized clinical trial published in The Lancet explored whether patients with a presumed cardiac origin cardiac arrest, but without ST segment elevation, benefited from being taken to a cardiac arrest center rather than a local emergency department. The study found no difference in all-cause mortality at 30 days between the two groups.
Timing of Appendectomy for Acute Appendicitis
A study published in The Lancet investigated the optimal timing of surgery for patients with acute appendicitis. The researchers found no significant difference in the rate of perforation between patients who underwent surgery within 8 hours versus those who underwent surgery within 24 hours. The results suggest that delaying surgery for up to 24 hours does not increase the risk of complications.
Use of Bicarbonate, Calcium, and Magnesium in Cardiac Arrest
An analysis published in Resuscitation examined the routine administration of bicarbonate, calcium, and magnesium during in-hospital cardiac arrest. The study used an instrumental variable analysis to assess the impact of these interventions on patient outcomes. The findings were inconclusive, with wide confidence intervals and conflicting results. Further research is needed to determine the effects of these drugs on cardiac arrest outcomes.
This month we kick off looking at an RCT which looks at whether we should convey patients with a ROSC from a likely cardiac cause (without a STEMI in their ECG) to a cardiac arrest centre, or whether they would be as well served at their local Emergency Department. This paper has huge potential implications for service design for cardiac arrest patients.
Next up we look at another RCT evaluating if patients with a suspected uncomplicated appendicitis who have urgent surgical intervention benefit in terms of a reduced perforation rate, when compared with those who have surgery within 24 hours.
Lastly we take a look at the use of bicarbonate, calcium and magnesium in cardiac arrest and see if there use is supported in a huge cardiac arrest registry.
Once again we’d love to hear any thoughts or feedback either on the website or via X @TheResusRoom!
Simon & Rob
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