I have Andie Crosby with me again for the second part of a two-part series on why cardiovascular health is the number one longevity lever for women.

Today, in Part 2, we explore how a healthy endothelial glycocalyx matrix helps your body produce more nitric oxide, which supports energy, sexual vitality, and even skin radiance. We also explain what could damage your ability to produce nitric oxide naturally.

If you have not yet done so, please listen to Part 1 first, to learn about the endothelial glycocalyx matrix before listening to Part 2.

How to Support Nitric Oxide Production

Maintain a healthy glycocalyx through diet, exercise, and lifestyle
Test your nitric oxide levels to know if you are deficient
Supplement strategically if your levels are low
Exercise regularly to increase nitric oxide during activity and improve recovery afterward

Bio: Andie Crosby

Andie Crosby is a seasoned business leader and passionate advocate for health and longevity.

After decades leading marketing and brand development for companies like Nike, Apple, and Procter & Gamble, her focus shifted in her 40s when she experienced firsthand the impact of hormonal changes, inflammation, and the power of nutrition to transform health.

A simple elimination diet revealed how profoundly food and lifestyle impacted her well-being, sparking a deep curiosity about health and healing.

This led her to The Institute for Functional Medicine, where she became the first Chief Marketing Officer.

Over ten years, Andie built IFM’s marketing and partnerships teams, driving a 13-fold increase in practitioner education and advancing personalized, systems-based care.

Today, as President of Calroy Health Sciences, Andie leads innovation in cardiovascular and joint health.

Her mission is to raise awareness of the vascular system’s foundational role - not only in disease prevention but also in longevity, brain health, and performance. She believes we have the tools to change the trajectory of our healthspan and empowers people to take control by asking the right questions.

Andie brings a relatable, purpose-driven perspective on living longer, better, and embracing midlife as a powerful opportunity for health transformation.

In this episode:

What is nitric oxide?
Why the glycocalyx is critical for nitric oxide production and blood vessel function
How nitric oxide affects blood pressure, circulation, sexual health, and recovery after exercise
How aging and lifestyle choices reduce natural nitric oxide
How to monitor your nitric oxide level
The benefits of targeted supplementation
Why proactive cardiovascular care is crucial

Links and Resources:

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