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JAMA Author Interviews

Sedentary Behavior and Dementia

Sep 12, 2023
David A. Raichlen from the University of Southern California joins Dr. Christopher C. Muth to discuss a study on the association between sedentary behavior and dementia in older adults. They explore the design and data sources of the study, uncover the nonlinear relationship between sedentary behavior and dementia, and discuss the importance of reducing sedentary time for brain health.
10:53

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Quick takeaways

  • The study found that sedentary behavior of around nine and a half to ten hours per day significantly increased the risk of dementia in older adults.
  • Reducing the overall volume of sedentary time may be more important than altering the patterns of sedentary behavior for reducing the risk of dementia.

Deep dives

Associations between sedentary behavior and incident dementia

The study explored the relationship between sedentary behavior and incident dementia among older adults. While there is evidence that physical activity reduces the risk of dementia, the study aimed to determine if sedentary behavior had independent effects. The researchers used data from the UK Biobank, analyzing the sedentary behavior patterns of individuals aged 60 and older by tracking accelerometers for six and a half years. The main finding was that risk of dementia increased significantly after around nine and a half to ten hours of daily sedentary behavior.

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