David A. Raichlen from the University of Southern California joins Dr. Christopher C. Muth to discuss a study on the association between sedentary behavior and dementia in older adults. They explore the design and data sources of the study, uncover the nonlinear relationship between sedentary behavior and dementia, and discuss the importance of reducing sedentary time for brain health.
The study found that sedentary behavior of around nine and a half to ten hours per day significantly increased the risk of dementia in older adults.
Reducing the overall volume of sedentary time may be more important than altering the patterns of sedentary behavior for reducing the risk of dementia.
Deep dives
Associations between sedentary behavior and incident dementia
The study explored the relationship between sedentary behavior and incident dementia among older adults. While there is evidence that physical activity reduces the risk of dementia, the study aimed to determine if sedentary behavior had independent effects. The researchers used data from the UK Biobank, analyzing the sedentary behavior patterns of individuals aged 60 and older by tracking accelerometers for six and a half years. The main finding was that risk of dementia increased significantly after around nine and a half to ten hours of daily sedentary behavior.
Implications and future research on sedentary behavior and dementia
The study's findings have implications for public health interventions to reduce sedentary behavior and potentially decrease the risk of dementia. While it is an observational study and causal relationships cannot be definitively established, future research could explore interventions targeting sedentary behavior, such as examining biomarkers of dementia risk or brain imaging biomarkers. The study suggests that reducing the overall volume of sedentary time may be more important than altering the patterns of sedentary behavior. Additionally, reducing sedentary time may be more feasible and effective than increasing physical activity levels.
There is an established link between sedentary behavior and cardiovascular disease, but the association between sedentary behavior and dementia is unclear. JAMA Deputy Editor Christopher C. Muth, MD, speaks with David A. Raichlen, PhD, University of Southern California, about a new study that investigates the relationship between sedentary behavior and dementia in older adults. Related Content: