Critical Care Time 53. Lactate & Lactic Acidosis
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Jul 14, 2025 Dive into the fascinating world of lactic acidosis! Understand the crucial role lactate plays in energy metabolism and the clinical implications of high levels in critical care. Learn about the distinctions between type A and type B lactic acidosis and their causes, including medication effects. Explore the importance of monitoring lactate levels and the complexities of diagnosing underlying issues. You'll gain valuable insights into managing this critical condition effectively!
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Lactate's Role in Energy Production
- Lactate is a 3-carbon breakdown product of pyruvate produced by cells to keep glycolysis running without oxygen.
- It helps cells extract some energy anaerobically but is less efficient than aerobic metabolism.
Lactate is Not Toxic
- Lactate itself is not harmful; elevated lactate reflects underlying physiology or pathology.
- For example, elite athletes have extremely high lactate but are very healthy.
Lactate vs. Lactic Acid Clarified
- Lactate and lactic acid are related but different: lactic acid releases protons lowering pH; lactate is its conjugate base and does not lower pH.
- This distinction helps clarify confusion around lactated Ringer's solution use.