GasGasGas - The FRCA Primary Exam Podcast GasGasGas - Clonidine
Oct 3, 2025
Explore the fascinating world of clonidine, an alpha-2 partial agonist with a rich history and diverse applications in anesthesia. Learn about its various forms, from tablets to patches, and its crucial role in pain management and sedation. Discover dosing intricacies, off-label uses, and the potential risks of withdrawal. Delve into the cardiovascular effects, CNS interactions, and unique pharmacokinetics that make this drug both versatile and complex. This discussion promises to expand your medical knowledge and understanding!
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Partial Alpha-2 Mechanism Explains Mixed Effects
- Clonidine is a partial alpha-2 adrenoceptor agonist that inhibits noradrenaline release and produces sedation and some analgesia.
- Its analgesic mechanism may involve reduced substance P or increased endogenous opioid release depending on the literature.
From Decongestant To Anaesthetic Adjunct
- Clonidine was synthesised in 1962 and initially used as a nasal decongestant and later as an antihypertensive.
- Dr Gas Lurks notes its route from odd early uses into premed and anaesthetic practice.
Dose And Avoid Abrupt Withdrawal
- Use intravenous clonidine doses around 1–3 µg/kg for analgesia, blood pressure control and sedation, with onset ~10 minutes and offset over 3–7 hours.
- Avoid abrupt cessation after infusion because sudden withdrawal causes marked hypertension and agitation; step down to oral dosing instead.