High Intensity Health with Mike Mutzel, MS The LDL Cholesterol Story is Falling Apart: Focus on THIS Instead
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Dec 5, 2024 Recent research challenges the significance of LDL cholesterol in heart disease, revealing that poor metabolic health and low HDL may be better indicators of coronary artery calcium. The discussions highlight the vital role of HDL size in protecting against coronary artery disease and the correlation between triglycerides and various health risks. Lifestyle changes can enhance HDL levels, while exercise is shown to increase its protective qualities. The podcast emphasizes a shift in focus from cholesterol levels to overall metabolic health for better cardiovascular outcomes.
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LDL vs. HDL
- LDL cholesterol doesn't strongly correlate with coronary artery atherosclerosis.
- HDL cholesterol, especially larger particles, is more protective against metabolic disease and plaquing.
Triglyceride Enrichment
- Lipoprotein particles (LDL, HDL, VLDL) become enriched with triglycerides as insulin resistance develops.
- This triglyceride enrichment correlates with coronary artery atherosclerosis and a higher propensity for diabetes.
LDL and Diabetes Paradox
- Studies show LDL cholesterol levels may be lower in individuals with diabetes compared to those without.
- This is perplexing since heart disease is the leading cause of death in diabetics.