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The Drug Discovery World Podcast

A safer option to opioid pain killers

Jan 29, 2024
Dr. Lynn Kirkpatrick, CEO of Ensysce Biosciences, discusses the development of a safer option to opioid pain killers that prevents abuse and overdose. Topics include Tripsin-Activated Abuse Protection, the MPAR approach to prevent prescription opioid overdose, and the advancement of a FDA approved product for chronic severe pain patients.
15:09

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Quick takeaways

  • TAP chemical approach prevents abuse by inactivating opioids until swallowed, showcasing safer pain relief.
  • MPAR products offer both abuse and overdose protection by controlling opioid release, making opioids safer for patients.

Deep dives

Developing TAP - a Safer Option to Opioid Painkillers

N-Sized Biocciences is developing TAP (Tripsin-Activated Abuse Protection), a chemical approach to reducing abuse of opioids. Unlike physical deterrents, TAP is engineered at the chemical level to prevent abuse by making the opioid inactive until it's swallowed, and harder to break. Clinical data shows that TAP has the same pain-relieving effects as opioids but lasts longer and reduces the risk of abuse. This next-generation opioid addresses the dueling crises of chronic pain and abuse by providing safer pain relief.

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