Dealing with Chronic Pain and Joint Injuries. Regenerative Medicine, Cellular Dosing, & Biohacking that Transforms Your Body. Dr David Karli MD
Mar 25, 2025
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Dr. David Karli, a renowned leader in regenerative medicine, shares his expertise on innovative treatments for chronic pain and joint injuries. He discusses the importance of cellular dosing and its pivotal role at the Karli Center. Listeners will learn why regenerative medicine hasn’t gained popularity, the potential of regenerating the knee meniscus, and the benefits of combining therapies like ozone and red light. Karli advocates for a personalized approach to treatment, explaining how hormone optimization can enhance recovery and overall health.
The simple act of dinner took on a new dimension for the Emperors. In an place where every meal could be a performance, an Emperor used the chance to reward and impress, intimidate and strike fear, and sometimes all at once. Having dinner with the Emperor was always a great honour, but sometimes you were risking your life.
Episode CCXXXVIII (238)
Guest:
Professor Mary Beard (Classics and Ancient History, La Trobe University)
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Quick takeaways
Chronic pain significantly impacts overall well-being, underscoring the need for innovative approaches like regenerative medicine to enhance quality of life.
Despite skepticism surrounding regenerative therapies, tracking individualized treatment outcomes reveals notable success rates in managing conditions like knee arthritis.
Cellular dosing is crucial for improving the predictability of regenerative treatments, as it ensures accurate measurement and tailored approaches to patient care.
Deep dives
The Impact of Chronic Pain on Lifestyle
Chronic pain significantly alters daily life by draining energy and affecting mental and emotional health. It often hinders individuals from maintaining healthy lifestyles, such as regular exercise, which can further exacerbate feelings of helplessness. The inability to move freely and engage in activities can lead to a decline in overall well-being. Understanding this impact is crucial for recognizing the importance of innovative medical approaches like regenerative medicine in addressing these issues.
Understanding Regenerative Medicine
Regenerative medicine aims to heal the body from within, yet many current practices do not fully achieve this goal. The focus is primarily on using living cells to manage diseases and promote healing, especially in orthopedic conditions. Despite advancements, many medical professionals remain skeptical about the potential for regeneration, particularly in avascular structures like cartilage, which complicates traditional healing processes. Realizing the limitations while striving for advancements remains a core challenge in regenerative medicine.
Success Rates and Variables in Treatment
Tracking treatment outcomes is vital for understanding the efficacy of regenerative therapies; notable success rates are often reported, particularly in managing knee arthritis. By closely examining patient data, trends have emerged showing that a significant percentage achieve functional restoration and pain relief. However, the complexity of factors influencing these outcomes necessitates individualized treatment plans based on varying patient conditions and histories. Encouragingly, this data-driven approach allows practitioners to refine protocols to enhance patient outcomes.
The Role of Cellular Dosing in Therapy
Cellular dosing is essential in optimizing therapies, aiming for accurate measurement of biologic products administered to patients. Historically, practices like PRP and stem cell therapy often lacked standardization, leading to unpredictable results. Developing methods to measure cellular constituents reliably has become a priority, allowing for tailored treatment approaches based on precise patient needs. This focus on dosage will ultimately help improve the predictability of success rates in regenerative treatments, enhancing patient confidence in these therapies.
Integrating Functional and Regenerative Medicine
Functional medicine and regenerative medicine complement each other, offering a holistic approach to patient care by considering overall health rather than isolated symptoms. Hormonal health, nutrition, and lifestyle factors play a significant role in recovery, emphasizing the importance of addressing these elements. Collaboration across various medical disciplines is necessary for improving patient outcomes, particularly in chronic conditions. As the fields converge, the potential for advancements in treatment modalities expands, providing hope for better health management strategies.
I have been practicing regenerative medicine for nearly two decades, and I don’t know why it hasn’t taken off like I expected. I asked that question to Dr David Karli why he believes that is the case, and what he is doing to pioneer new techniques that produce better outcomes. This is a deep-dive, technical episode about the art and science of regenerative medicine, and in which situations it is the most appropriate model of care.
Dr. David Karli is a renowned leader in the field of Regenerative Medicine. He is an internationally known physician entrepreneur and respected author and lecturer in the field, having dedicated over twenty years of his life to perfecting life altering orthobiologic procedures for his patients. Many of his patients are long standing and travel thousands of miles to seek his care. He opened the Karli Center in March 2023 in Miami to create a focused resource, specifically devoted to advancing and delivering biological therapies, easily accessible to both national and international patients.
Join us as we explore:
Clearing up the confusion around regenerative medicine - what it is, what’s the goal, why it hasn’t taken off like I believe it should and Dr Karli’s practice of the art.
Cellular dosing - what is is, how it works and why it is at the center of the Karli Center.
Why it is misguided to to spend thousands and thousands on biohacking and therapies but you are not putting your OWN cells to work for you.
Whether the meniscus can be regenerated.
How functional medicine and regenerative medicine are going to intersect.
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