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Raising Health
Drag & Drop Genome Editing
Jan 16, 2024
Rahul Kakkar, John Finn, and Jorge Conde discuss PASTE, a genome editing technique that could make cell therapy more accessible. They explore advancements in genomic medicine, CRISPR technology, and focus on genetic diseases of the liver and autoimmune diseases. They also touch on challenges in transitioning from research to patients and share anecdotes about facial hair.
30:08
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Quick takeaways
- Using the PASTE technology, Tome Bio Sciences aims to make cell therapy more accessible, scalable, and transform it from a niche product to a discovery platform.
- Tome's PAST technology allows for the precise insertion of any sequence of DNA code in any location, revolutionizing the treatment of genetic diseases and enabling rapid iteration and scale in cell therapy.
Deep dives
TOM: A Powerful Genome Editing Technique
Rahul Kukar, CEO of Tone Bio Sciences, and John Finn, CSO, discuss the technology behind TOM, known as PAST, a combination of two older technologies. PAST utilizes a Cas9 Nikkez with an RT enzyme to programably write a landing site for a specific integrase protein, allowing the precise insertion of DNA code. This technology has the potential to make cell therapy more accessible and scalable, transforming it from a niche product to a discovery platform.
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Discover
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Listen to the best highlights from the podcasts you love and dive into the full episode