Ep. 44 Innate Immune System featuring Dr. Miriam Merad

Guest:

Dr. Miriam Merad is a Professor of Cancer Immunology and Director of the Marc and Jennifer Lipschultz Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai. Her research focuses on dendritic cells and macrophages. She talks about tissue-resident macrophages in COVID-19 and cancer. She also discusses her new role as President of the International Union of Immunological Societies and bringing the international immunology community together at their upcoming meeting in South Africa.

Featured Products and Resources:

The Immunology Science Round Up

NLRP3 Inflammasome Activation – Researchers used cryo-EM to identify the structure of the active NLRP3 inflammasome disk.

How the BCG Vaccine Induces Trained Immunity – The BCG vaccine triggers epigenetic modifications on alveolar macrophages via an intestinal microbiota-mediated pathway.

Immunotherapy for Type 1 Diabetes – Scientists examined the mechanism of action of low-dose interleukin-2 immunotherapy and identified a long-lived gene expression signature associated with potential anti-inflammatory effects.

pH Affects Interleukin-2 Anti-Tumor Activity – Researchers identified an interleukin-2 variant that retains its binding affinity in low pH environments.

Image courtesy of Dr. Miriam Merad

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