In this enlightening discussion, Sam Harris talks with Ben Lamm, a tech entrepreneur and co-founder of Colossal Biosciences, focusing on the ambitious goal of de-extincting species like the woolly mammoth. Lamm explains the innovative use of AI and CRISPR technology in his company's efforts and contrasts these with the fictional portrayal in Jurassic Park. They delve into the potential ecological benefits of bringing back these species, the ethical implications, and how this work could impact human health and biodiversity.
Colossal Biosciences aims to resurrect extinct species like the woolly mammoth by using genomic similarities and advanced editing techniques.
Artificial intelligence enhances the de-extinction process by optimizing genetic editing methods and reducing the experimental trial-and-error approach.
Deep dives
The Vision of De-Extinction
Colossal Biosciences is focused on the ambitious goal of resurrecting extinct species, such as the woolly mammoth, Tasmanian tiger, and dodo, to address biodiversity loss. The company aims to apply emerging technologies in synthetic biology and AI to revitalize these species and restore ecological balance. Ben Lamb emphasizes that the alarming predictions regarding biodiversity loss could see up to 50% of species disappearing by 2050, thus underlining the necessity of innovative approaches for species preservation. This initiative is not only about reviving these animals but also about utilizing the scientific advancements for broader applications, including human healthcare.
Innovative Techniques in Genetic Engineering
The methodology employed by Colossal differs significantly from public misconceptions often associated with Jurassic Park. Instead of attempting to fill in DNA gaps with species from millions of years ago, the approach uses the genomic similarities between extinct species and their closest living relatives, such as the Asian elephant for the woolly mammoth. Advanced techniques, including comparative genomics and the potential for multiplex editing, allow for precise modifications in living cells, setting the groundwork for de-extinction. This reverse engineering approach identifies key genetic traits necessary for each species’ survival and enables the introduction of these traits into the genomes of existing animals.
AI's Role in De-Extinction Processes
Artificial intelligence plays a crucial role in enhancing the efficiency of the de-extinction process by optimizing editing techniques and reducing experimental time. Colossal has developed internal tools that accurately recommend editing methods based on specific genetic targets, which can significantly minimize the trial-and-error nature of genetic engineering. Lamb explains that advancements in AI are proving beneficial not just for selecting appropriate editing tools, but also for comparative genomics and analyzing the resulting genetic changes. This integration of technology accelerates the potential for successful de-extinction, making what once seemed like science fiction much closer to reality.
Sam Harris speaks with Ben Lamm about his work at Colossal Biosciences. They discuss his efforts to de-extinct the woolly mammoth, the Tasmanian tiger, and the dodo; the difference between Colossal’s approach and Jurassic Park; the details of resurrecting the mammoth; the relevance of this work to human health; the role of artificial intelligence; reintroducing mammoths, Tasmanian tigers, and dodos back into the wild; the environmental and business case for de-extinction; and other topics.
If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.
Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.
Get the Snipd podcast app
Unlock the knowledge in podcasts with the podcast player of the future.
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode
Save any moment
Hear something you like? Tap your headphones to save it with AI-generated key takeaways
Share & Export
Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode