ICU Primary PrepCast #Epi 87 - ICU Primary Snippet 30 - Opioid Receptors
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Apr 1, 2024 Exploring opioid receptor classification, structure, distribution, and activation process for pain control, mood regulation, and reward centers. Discussing types of receptors, their mechanism in inhibiting nociceptive transmission, and analgesic effects.
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Opioid Receptor Classification
- Opioid receptors are classified into four types: mu, delta, kappa, and nociceptin.
- The nociceptin receptor differs because it doesn't respond to naloxone, an opioid antagonist.
Opioid Receptor Structure
- All opioid receptors are G protein-coupled receptors with seven transmembrane alpha helices.
- Ligands bind to specific pockets within these helices, causing intracellular events.
Opioid Receptor Distribution
- Opioid receptors are distributed throughout the CNS and peripheral nervous system.
- They're found in areas related to pain, mood, reward, and other functions like the GI tract.