
Invest Like the Best with Patrick O'Shaughnessy
Alex Telford - Unlocking Innovation in Pharma - [Invest Like the Best, EP.360]
Jan 30, 2024
Alex Telford, founder of Convoke and biotech blogger since 2019, dives into the evolving landscape of the pharmaceutical industry. He discusses the intricate journey of drug development, emphasizing the role of AI in enhancing drug discovery and the regulatory challenges surrounding it. Telford also explores the economics of blockbuster drugs and the balance between affordability and innovation. With insights into the future of biotechnology, including CRISPR and CAR T therapies, he paints an optimistic picture of what's next for medicine.
59:30
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Quick takeaways
- Emerging technologies like gene therapy, cell therapy, and radiopharmaceuticals offer new possibilities for improving drug development and treatment efficacy.
- The pharmaceutical industry's reliance on blockbuster economics limits investment in drugs for niche markets or rare diseases, leaving patients without viable treatment options.
Deep dives
Drug Development Process and Challenges
The pharmaceutical industry's drug development process begins with academic research funded by organizations like the NIH to understand disease mechanisms and identify potential targets. Biotech companies then take these ideas and work to convert them into drugs through extensive testing, starting with in vitro studies and progressing to human trials. Regulatory agencies review the data to determine if a drug can be marketed. However, the industry faces challenges such as the slow pace of development, restrictive regulations, and the dwindling availability of low-hanging fruit. Emerging technologies like gene therapy, cell therapy, and radiopharmaceuticals offer new possibilities for improving drug development and treatment efficacy.
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