Free Radicals NewLimit Co-Founder Jacob Kimmel on Reversing Aging with Predictive Biology
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Jan 13, 2026 
In this engaging discussion, Jacob Kimmel, co-founder of NewLimit, explores the frontier of biotechnology to reverse aging. He defines aging as loss of function linked to evolutionary pressures and introduces epigenetic reprogramming as a game-changing approach. Kimmel highlights the importance of data-driven models in predictive biology and discusses how NewLimit's innovative therapies aim to rejuvenate cells. He also emphasizes achievable longevity goals while warning against extreme lifespan fantasies, making a compelling case for the science of aging.
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Aging As Entropy And Evolutionary Default
- Jacob Kimmel defines aging as loss of cellular and tissue function driven by entropy and insufficient evolved regulation.
- Evolution prioritized reproduction, so late-life maintenance lacked selective pressure and declines by default.
Why Late-Life Harm Persists
- Antagonistic pleiotropy may persist because alleles that help early-life fitness face little negative selection later.
- High baseline mortality in primate evolution reduced selection pressure for late-life protective alleles.
Epigenome Has Biggest Reversal Effects
- Epigenetic reprogramming shows the largest intervention effect sizes for restoring youthful cellular function.
- Other interventions like metabolic changes yield smaller, inconsistent lifespan bumps.