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Healio Rheuminations

IgG4-related Disease with John Stone, MD

Jul 3, 2019
24:54

John Stone, MD, MPH, is the world leader in the field of IgG4-related disease research. In this episode, he breaks down the histology of IgG4-related disease, important aspects of what is known about the pathophysiology of the disease, as well as future directions in treatment.

  • Intro :10
  • Inside this episode :13
  • IgG4-related disease background :31
  • An anecdote 1:15
  • The interview 4:09
  • History of IgG4-related disease 4:18
  • IgG4 pathology and terms 7:48
  • What makes IgG4 different from other IgG subclasses? 10:23
  • What do we know about the interplay between B and T cells? 12:31
  • What is SLAMF7? 16:30
  • What happens to T cells during B-cell depletion? 18:22
  • Antigens involved in IgG4 21:06
  • Future of treatment 23:10
  • Thank you, Dr. Stone 24:32

We’d love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum

John Stone, MD, MPH, is director of clinical rheumatology at Massachusetts General Hospital.

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