John Stone, MD, MPH, is the world leader in the field of IgG4-related disease research. In this episode, he breaks down the histology of IgG4-related disease, important aspects of what is known about the pathophysiology of the disease, as well as future directions in treatment.

• Intro :10
• Inside this episode :13
• IgG4-related disease background :31
• An anecdote 1:15
• The interview 4:09
• History of IgG4-related disease 4:18
• IgG4 pathology and terms 7:48
• What makes IgG4 different from other IgG subclasses? 10:23
• What do we know about the interplay between B and T cells? 12:31
• What is SLAMF7? 16:30
• What happens to T cells during B-cell depletion? 18:22
• Antigens involved in IgG4 21:06
• Future of treatment 23:10
• Thank you, Dr. Stone 24:32

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John Stone, MD, MPH, is director of clinical rheumatology at Massachusetts General Hospital.