Jon Hamilton, NPR Science Correspondent, dives into the promising but complex world of newly approved Alzheimer's drugs. He shares personal stories from patients navigating the challenges of the disease. One woman’s experience in a clinical trial sheds light on the emotional toll alongside potential hope. They discuss the drugs' effectiveness, risks, and how they target beta amyloid plaques. The podcast beautifully intertwines science with human experiences, reminding us of the delicate balance between medical advancements and individual journeys.
The FDA-approved Alzheimer's drugs can moderately slow mental decline but their effectiveness varies significantly among individuals.
Patient experiences reveal that while some may find temporary cognitive stability, many face the sobering reality of diminishing benefits over time.
Deep dives
Introduction to Alzheimer's Treatments
Two drugs have gained FDA approval for treating early-stage Alzheimer's disease, targeting the removal of beta amyloid plaques in the brain. Both drugs require intravenous infusion and come with a significant cost of over $25,000 per year. While effective in clearing amyloid, the drugs only moderately slow the progression of symptoms, showcasing benefits that can vary widely among individuals. This uncertainty often drives patients to try these medications despite the risks involved, including potential severe side effects like brain swelling.
Sue Bell's Experience with Lakembi
Sue Bell participated in a clinical trial for the drug Lakembi, which she began taking in 2020. Initially, the drug seemed to provide her with some cognitive stability, allowing her to enjoy memorable experiences, like a trip to New York with family. However, as her Alzheimer's progressed, she and her husband decided to discontinue the treatments, recognizing that the drug had ceased to provide any meaningful benefit. Their situation highlights the reality faced by many patients, where hope can fade even as they seek treatment options.
Mayra Solano-Garcia's Journey with Casunla
Mayra Solano-Garcia, diagnosed with Alzheimer's, participated in a study for the drug Casunla, undergoing monthly infusions for treatment. While her cognitive abilities did not significantly improve, she has not experienced rapid decline, indicating a potential stabilization effect. After four years on the medication, she anticipates concluding her treatment, although she still grapples with the realities of her condition, such as losing musical skills and her professional career. Solano-Garcia remains active in her community, volunteering and sharing her musical talents, reflecting a resilient spirit despite the challenges of Alzheimer's.
There are now two fully approved drugs on the market that can, sometimes, slow down the progression of Alzheimer's disease. Both have been shown to slow down the mental decline of Alzheimer's by more than 25%. But that's in a group of patients—an individual may do much better, or not be helped at all. NPR Science Correspondent Jon Hamilton has been talking to people who've taken these drugs. Today he has the story of two patients to receive them.
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