Critical Matters Management of C-difficile Infection (CDI)
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Apr 9, 2021 Join Dr. Max Adelman, an infectious diseases expert from Emory University, as he dives into the critical management of Clostridioides difficile infections. They discuss the dramatic rise of CDI in hospitals and its ties to antibiotic use. Learn about key strategies for effective treatment, including the optimal dosing of oral vancomycin and the role of fecal microbiota transplants. Dr. Adelman also shares insights on surgical interventions and draws intriguing parallels between historical pandemics and today's health challenges.
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C. difficile Is The Top HA Infection
- Clostridioides difficile is the most common hospital-acquired infection in the U.S. with ~500,000 cases yearly and ~half hospital-acquired.
- Many cases now start in the community, so clinicians across settings must recognize CDI risk and presentation.
ICU Cases Carry High Mortality
- About 5–15% of hospitalized C. diff patients will need ICU care and mortality can reach 20–30% for those admitted for CDI.
- Diarrhea in ICU patients is common, but only ~10–15% of ICU diarrhea is due to C. diff.
Steward Antibiotics To Reduce CDI
- Avoid unnecessary broad-spectrum antibiotics because they disrupt the gut microbiome and raise CDI risk.
- Prefer narrower agents and daily reassessment to reduce C. diff incidence in hospitalized patients.
